New Syllabus for GATE Biotechnology | Gyan Bindu Academy Pvt Ltd in South West Delhi

GATE Biotechnology Syllabus

Course Syllabus

Section 1: Engineering Mathematics

Linear Algebra: Matrices and determinants, Systems of linear equations, Eigenvalues, and Eigenvectors. Calculus: Limit, continuity and differentiability, Partial derivatives, Maxima and minima, Sequences and series, Test for convergence, Fourier Series. Differential.

Equations: Linear and nonlinear first-order ODEs, higher-order ODEs with constant coefficients equations, Laplace transforms, PDE-Laplace, heat, and wave equations. Probability and Statistics: Mean, median, mode and standard deviation, Random variables, Poisson, normal and binomial distributions, Correlation, and regression analysis. Numerical Methods: Solution of linear and nonlinear algebraic equations, Integration of trapezoidal and Simpson rule, Single and multistep methods for differential equations.

Section 2: General Biotechnology

Biochemistry: Biomolecules-structure and functions; Biological membranes, structure, action potential and transport processes; Enzymes- classification, kinetics, and mechanism of action; Basic concepts and designs of metabolism (carbohydrates, lipids, amino acids, and nucleic acids) photosynthesis, respiration, and electron transport chain; Bioenergetics

Microbiology: Viruses- structure and classification; Microbial classification and diversity (bacterial, algal, and fungal); Methods in microbiology; Microbial growth and nutrition; Aerobic and anaerobic respiration; Nitrogen fixation; Microbial diseases and host-pathogen interaction.

Cell Biology: Prokaryotic and eukaryotic cell structure; Cell cycle and cell growth control; Cell-Cell communication, Cell signaling, and signal transduction

Molecular Biology and Genetics: Molecular structure of genes and chromosomes; Mutations and mutagenesis; Nucleic acid replication, transcription, translation, and their regulatory mechanisms in prokaryotes and eukaryotes; Mendelian inheritance; Gene interaction; Complementation; Linkage, recombination, and chromosome mapping; Extra chromosomal inheritance; Microbial genetics (plasmids, transformation, transduction, conjugation); Horizontal gene transfer and Transposable elements; RNA interference; DNA damage and repair; Chromosomal variation; Molecular basis of genetic diseases Analytical Techniques: Principles of microscopy-light, electron, fluorescent and confocal; Centrifugation- high speed and ultra; Principles of spectroscopy-UV, visible, CD, IR, FTIR, Raman, MS, NMR; Principles of chromatography- ion exchange, gel filtration, hydrophobic interaction, affinity, GC, HPLC, FPLC; Electrophoresis; Microarray

Immunology: History of Immunology; Innate, humoral and cell-mediated immunity; Antigen; Antibody structure and function; Molecular basis of antibody diversity; Synthesis of antibody and secretion; Antigen-antibody reaction; Complement; Primary and secondary lymphoid organ; B and T cells and macrophages; Major histocompatibility complex (MHC); Antigen processing and presentation; Polyclonal and monoclonal antibody; Regulation of immune response; Immune tolerance; Hypersensitivity; Autoimmunity; Graft versus host reaction.

Bioinformatics: Major bioinformatic resources and search tools; Sequence and structure databases; Sequence analysis (biomolecular sequence file formats, scoring matrices, sequence alignment, phylogeny); Data mining and analytical tools for genomic and proteomic studies; Molecular dynamics and simulations (basic concepts including force fields, protein-protein, protein-nucleic acid, protein-ligand interaction)

Section 3: Recombinant DNA Technology

Restriction and modification enzymes; Vectors; plasmid, bacteriophage, and other viral vectors, cosmids, Ti plasmid, yeast artificial chromosome; mammalian and plant expression vectors; cDNA and genomic DNA library; Gene isolation, cloning, and expression; Transposons and gene targeting; DNA labeling; DNA sequencing; Polymerase chain reactions; DNA fingerprinting; Southern and northern blotting; In-situ hybridization; RAPD, RFLP; Site-directed mutagenesis; Gene transfer technologies; Gene therapy

Section 4: Plant and Animal Biotechnology

Totipotency; Regeneration of plants; Plant growth regulators and elicitors; Tissue culture and Cell suspension culture system: methodology, the kinetics of growth and, nutrient optimization; Production of secondary metabolites by plant suspension cultures; Hairy root culture; transgenic plants; Plant products of industrial importance Animal cell culture; media composition and growth conditions; Animal cell and tissue preservation; Anchorage and non-anchorage dependent cell culture; Kinetics of cell growth; Micro & macro-carrier culture; Hybridoma technology; Stem cell technology; Animal cloning; Transgenic animals

Section 5: Bioprocess Engineering and Process Biotechnology

Chemical engineering principles applied to biological system, Principle of reactor design, ideal and non-ideal multiphase bioreactors, mass and heat transfer; Rheology of fermentation fluids, Aeration and agitation; Media formulation and optimization; Kinetics of microbial growth, substrate utilization and product formation; Sterilization of air and media; Batch, fed-batch and continuous processes; Various types of microbial and enzyme reactors; Instrumentation control and optimization; Unit operations in solid-liquid separation and liquid-liquid extraction; Process scale-up, economics and feasibility analysis Engineering principle of bioprocessing- Upstream production and downstream; Bioprocess design and development from lab to industrial scale; Microbial, animal and plant cell culture platforms; Production of biomass and primary/secondary metabolites; Biofuels, Bioplastics, industrial enzymes, antibiotics; Large scale production and purification of recombinant proteins; Industrial application of chromatographic and membrane-based bioseparation methods; Immobilization of biocatalysts (enzymes and cells) for bioconversion processes; Bioremediation-Aerobic and anaerobic processes for stabilization of solid / liquid wastes.

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Our Customer Review

“Studying at Gyan Bindu Academy was most enriching experience. I would like to thank the faculty and management staff. The personal guidance of faculty helped me to crack the exam, which ultimately led me to a successful career in my life..”

Reviewed By : BILAL AHMAD HAKIM, [UGC-JRF (380987), RANK-67], New Delhi

“Motivated and committed faculty is the strength of the academy. Regular tests are another important feature. I was very much sure of my success because of the proper strategy, regular lectures and weekly tests conducted by the academy. I express my heartfelt thanks to GBA and shall remain grateful to the academy for showing this successful day in my life..”

Reviewed By : MEGHA [GATE - BIOTECHNOLOGY (36282113) RANK -4 ], New Delhi

“Yes, of course it is a valuable learning experience. I love it, it relates to all the things I am presently preparing for my exams and I am finding it extremely useful. I love getting my corrected assignments back. It is always an exciting moment, which I share with my family at dinner table. The course was more in-depth than I thought it would be and I could apply the information with my own thoughts..”

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“I have had a good experience with the entire Gyan Bindu Academy team who were very supportive throughout the session. In fact, the support of the faculty was second to none. They had an excellent attitude towards the students and encourage for further efforts and independent learning. I found the experience very motivational. I express my sincere thanks to the academy for helping me in qualifying JRF- NET exam. From the core of my heart, I wish Gyan Bindu Academy a bright future..”

Reviewed By : SHIV KUMAR YADAV, [ICMR - JRF (30132)], New Delhi

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